{"id":4595,"date":"2026-11-15T15:48:09","date_gmt":"2026-11-15T07:48:09","guid":{"rendered":"https:\/\/www.heimaobook.com\/?p=4595"},"modified":"2026-11-15T15:48:09","modified_gmt":"2026-11-15T07:48:09","slug":"%e7%a5%9e%e5%9f%ba%e5%88%b6%e8%8d%af%e6%97%97%e4%b8%8b%e5%81%8f%e5%a4%b4%e7%97%9b%e5%88%9b%e6%96%b0%e4%ba%a7%e5%93%81%e8%89%be%e4%b9%85%e7%bb%b4-%e5%a4%ab%e7%91%9e%e5%a5%88%e7%8f%a0%e5%8d%95","status":"publish","type":"post","link":"https:\/\/www.heimaobook.com\/?p=4595","title":{"rendered":"\u795e\u57fa\u5236\u836f\u65d7\u4e0b\u504f\u5934\u75db\u521b\u65b0\u4ea7\u54c1\u827e\u4e45\u7ef4\u00ae \u592b\u745e\u5948\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\u6210\u529f\u7eb3\u51652026\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55"},"content":{"rendered":"

\u200b11\u670814\u65e5\uff0c\u795e\u57fa\u5236\u836f\u5ba3\u5e03\uff0c\u65d7\u4e0b\u81ea\u68af\u74e6\uff08Teva\uff09\u5f15\u8fdb\u65b0\u836f\u827e\u4e45\u7ef4<\/span>\u00ae<\/span><\/sup>\uff08\u592b\u745e\u5948\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u6210\u529f\u901a\u8fc7\u56fd\u5bb6\u533b\u4fdd\u8c08\u5224\uff0c\u6b63\u5f0f\u88ab\u7eb3\u5165\u65b0\u7248\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f551<\/span><\/sup><\/span>\u3002\u4f5c\u4e3a\u9996\u4e2a\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u7684CGRP\u9776\u5411\u836f\u7269\uff0c<\/span>\u827e\u4e45\u7ef4<\/span><\/strong>\u00ae<\/span><\/sup><\/strong>\u5b9e\u73b0\u4e86\u201c6\u6708\u83b7\u6279\u3001\u5f53\u5e74\u5165\u4fdd\u201d\uff0c<\/span><\/strong>\u6709\u671b<\/span><\/strong>\u663e\u8457\u63d0\u5347<\/span><\/strong>\u504f\u5934\u75db<\/span><\/strong>\u521b\u65b0\u7597\u6cd5\u7684\u53ef\u53ca\u6027<\/span><\/strong>\uff0c\u51cf\u8f7b\u4e2d\u56fd\u60a3\u8005\u957f\u671f\u7528\u836f\u8d1f\u62c5<\/span><\/strong>\u3002<\/span><\/p>\n

<\/span><\/p>\n

<\/p>\n

\"\u914d\u56fe<\/p>\n

<\/p>\n

<\/span><\/p>\n

\u2022\u00a0<\/span>\u827e\u4e45\u7ef4<\/span><\/strong>\u00ae<\/span><\/sup><\/strong>\u662f\u4e00\u79cd\u9776\u5411\u964d\u9499\u7d20\u57fa\u56e0\u76f8\u5173\u80bd\uff08CGRP\uff09\u914d\u4f53\u7684\u5355\u514b\u9686\u6297\u4f53<\/span><\/span>2<\/span><\/sup><\/p>\n

\u2022\u00a0<\/span>\u76ee\u524d\u5df2\u4e0a\u5e02\u7684CGRP\u5355\u6297\u7c7b\u836f\u7269\u4e2d\uff0c\u592b\u745e\u5948\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\u662f\u552f\u4e00\u5177\u6709\u201c\u6bcf\u6708\u4e00\u6b21\u201d\u6216\u201c\u6bcf\u5b63\u5ea6\u4e00\u6b21\u201d\u4e24\u79cd\u53ef\u9009\u7ed9\u836f\u65b9\u6848\u7684\u76ae\u4e0b\u6ce8\u5c04\u836f\u72693<\/span><\/sup><\/span><\/p>\n

\u2022\u00a0<\/span>\u552f\u4e00\u5355\u72ec\u5f00\u5c55\u4e2d\u56fd\u4eba\u7fa4\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684CGRP\u5355\u62974<\/span><\/sup><\/span>\uff0c\u591a\u9879\u5173\u952e\u4e34\u5e8a\u7814\u7a76\u652f\u6301\u592b\u745e\u5948\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\u5728\u6210\u4eba\u504f\u5934\u75db\u9884\u9632\u6027\u6cbb\u7597\u4e2d\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027<\/span>5,6,7<\/span><\/sup><\/p>\n


<\/p>\n

\u795e\u57fa\u5236\u836f\u9996\u5e2d\u6267\u884c\u5b98\u9648\u9e4f\u4e98\u8868\u793a\uff1a<\/span><\/strong>\u201c<\/span>\u592b\u745e\u5948\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\u4f5c\u4e3a<\/span><\/strong>\u504f\u5934\u75db<\/span><\/strong>\u7684\u7a81\u7834\u6027\u521b\u65b0\u751f\u7269\u5236\u5242\uff0c\u5b9e\u73b0\u2018\u5f53\u5e74\u83b7\u6279\u3001\u5f53\u5e74\u5165\u4fdd\u2019\uff0c\u79bb\u4e0d\u5f00\u56fd\u5bb6\u533b\u4fdd\u5c40\u5bf9\u4e34\u5e8a\u6025\u9700\u521b\u65b0\u836f\u7684\u5927\u529b\u652f\u6301\u3002<\/span><\/strong>\u8fd9\u4e0d\u4ec5\u52a0\u901f\u4e86\u521b\u65b0\u7597\u6cd5\u7684\u672c\u571f\u843d\u5730\uff0c\u66f4\u8ba9\u504f\u5934\u75db\u60a3\u8005\u771f\u6b63\u4eab\u53d7\u5230\u9ad8\u54c1\u8d28\u3001\u53ef\u8d1f\u62c5\u7684\u7528\u836f\u4fdd\u969c\u3002\u795e\u57fa\u5236\u836f\u5c06\u7ed3\u5408\u5168\u7403\u8d44\u6e90\u4e0e\u672c\u571f\u80fd\u529b\uff0c\u5168\u529b\u4fdd\u969c\u836f\u54c1\u7684\u5168\u56fd\u7a33\u5b9a\u4f9b\u5e94\uff0c\u8ba9\u5168\u7403\u521b\u65b0\u6210\u679c\u66f4\u5feb\u60e0\u53ca\u66f4\u591a\u4e2d\u56fd\u5bb6\u5ead\u3002\u201d<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u504f\u5934\u75db\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u6162\u6027\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u3002\u5f53\u524d\u5728\u4e2d\u56fd\u9884\u8ba1\u7ea6\u6709\u4e0a\u4ebf\u60a3\u8005<\/span>8<\/span><\/sup>\uff0c18\u81f365\u5c81\u4eba\u7fa4\u504f\u5934\u75db\u5e74\u60a3\u75c5\u7387\u4e3a9.3%<\/span>9<\/span><\/sup>\u3002<\/span>\u504f\u5934\u75db\u4e34\u5e8a\u5e38\u8868\u73b0\u4e3a\u53cd\u590d\u53d1\u4f5c\u7684\u4e2d\u91cd\u5ea6\u640f\u52a8\u6027\u5934\u75db\uff0c\u5e76\u53ef\u4f34\u968f\u6076\u5fc3\u3001\u5455\u5410\u3001\u754f\u5149\u548c\u754f\u58f0\u7b49\u75c7\u72b6<\/span>10<\/span><\/sup>\u3002\u7531\u4e8e\u75be\u75c5\u6613\u53cd\u590d\u53d1\u4f5c\u4e14\u75c5\u7a0b\u8f83\u957f\uff0c\u504f\u5934\u75db\u53ef\u80fd\u6301\u7eed\u5f71\u54cd\u60a3\u8005\u7684\u5de5\u4f5c\u6548\u7387\u53ca\u6574\u4f53\u751f\u6d3b\u8d28\u91cf<\/span>8<\/span><\/sup>\u3002<\/span>\u964d\u4f4e\u504f\u5934\u75db<\/span>\u53d1\u4f5c\u9891\u7387\u3001<\/span>\u6301\u7eed\u65f6\u95f4\u53ca\u4e25\u91cd\u7a0b\u5ea6\uff0c\u6539\u5584\u504f\u5934\u75db\u76f8\u5173\u6027\u5931\u80fd\uff0c\u63d0\u9ad8\u751f\u6d3b\u8d28\u91cf\uff0c<\/span>\u5df2\u6210\u4e3a\u6210\u4eba\u504f\u5934\u75db\u6cbb\u7597\u7684\u91cd\u8981\u76ee\u6807<\/span>9<\/span><\/sup>\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4f5c\u4e3a\u504f\u5934\u75db\u9884\u9632\u6027\u6cbb\u7597\u7684\u6838\u5fc3\u673a\u5236\uff0c<\/span>CGRP\u9776\u5411\u5355\u6297\u76ee\u524d\u5df2\u83b7\u5f97\u5305\u62ec\u300a<\/span><\/strong>CGRP\u9776\u5411\u6cbb\u7597<\/span><\/strong>\u662f\u504f\u5934\u75db<\/span><\/strong>\u9884\u9632\u6027\u6cbb\u7597<\/span><\/strong>\u7684\u4e00\u7ebf\u9009\u62e9\uff1a\u7f8e\u56fd\u5934\u75db\u534f\u4f1a\u7acb\u573a\u58f0\u660e\u66f4\u65b0\u300b<\/span><\/strong>11<\/span><\/sup><\/strong>\u3001<\/span><\/strong>\u300a\u4e2d\u56fd\u504f\u5934\u75db\u8bca\u6cbb\u6307\u5357\u300b<\/span><\/strong>9<\/span><\/sup><\/strong>\u3001<\/span><\/strong>\u300a\u4e2d\u56fd\u504f\u5934\u75db\u8bca\u65ad\u4e0e\u6cbb\u7597\u6307\u5357\u300b<\/span><\/strong>10<\/span><\/sup><\/strong>\u4ee5\u53ca\u300a\u836f\u7269\u8fc7\u5ea6\u4f7f\u7528\u6027\u5934\u75db\u8bca\u65ad\u4e0e\u6cbb\u7597\u4e2d\u56fd\u4e13\u5bb6\u5171\u8bc6\u300b<\/span><\/strong>12<\/span><\/sup><\/strong>\u7b49\u591a\u90e8\u56fd\u5185\u5916\u6743\u5a01\u6307\u5357\u4e0e\u5171\u8bc6\u7684\u660e\u786e\u63a8\u8350<\/span><\/strong>\u3002<\/span><\/p>\n

<\/span><\/p>\n

\u827e\u4e45\u7ef4\u5728\u534e\u5386\u7a0b\uff1a<\/span><\/strong><\/p>\n

2023\u5e74\uff0c\u83b7\u5e7f\u4e1c\u7701\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\uff0c\u7387\u5148\u642d\u4e58\u201c\u6e2f\u6fb3\u836f\u68b0\u901a\u201d\u653f\u7b56\u843d\u5730\u7ca4\u6e2f\u6fb3\u5927\u6e7e\u533a\uff1b<\/span><\/p>\n

2024\u5e74\uff0c\u901a\u8fc7\u5728\u4e2d\u56fdIII\u671f\u7814\u7a76\u8fbe\u6210\u4e3b\u8981\u7ec8\u70b9\u548c\u6240\u6709\u6b21\u8981\u7ec8\u70b9\uff0c\u8bc1\u5b9e\u5728\u4e2d\u56fd\u4eba\u7fa4\u4e2d\u7684\u7597\u6548<\/span>13<\/span><\/sup>\uff1b<\/span><\/p>\n

2026\u5e744\u6708\uff0c\u795e\u57fa\u5236\u836f\u4e0e\u68af\u74e6\u533b\u836f\u8fbe\u6210\u6218\u7565\u5408\u4f5c\uff0c\u83b7\u5f97<\/span>\u4ea7\u54c1<\/span>\u5728\u4e2d\u56fd\u5927\u9646\u5546\u4e1a\u5316\u7684\u72ec\u5bb6\u6743\u76ca<\/span>14<\/span><\/sup>\uff1b<\/span><\/p>\n

2026\u5e746\u6708\uff0c\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\uff0c\u7528\u4e8e\u6210\u4eba\u504f\u5934\u75db\u7684\u9884\u9632\u6027\u6cbb\u7597<\/span>15<\/span><\/sup>\uff1b<\/span><\/p>\n

2026\u5e741<\/span>1<\/span>\u6708\uff0c\u6210\u529f\u901a\u8fc7\u56fd\u5bb6\u533b\u4fdd\u8c08\u5224\uff0c\u6b63\u5f0f\u88ab\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55<\/span>1<\/span><\/sup>\u3002<\/span><\/p>\n


<\/p>\n

\u5173\u4e8e\u827e\u4e45\u7ef4<\/span><\/strong>\u00ae<\/span><\/sup><\/strong>\uff08\u592b\u745e\u5948\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09<\/span><\/strong><\/p>\n

\u827e\u4e45\u7ef4<\/span>\u00ae<\/span><\/sup><\/strong>\u662f\u68af\u74e6\u533b\u836f\u521b\u65b0\u7814\u53d1\u7684\u504f\u5934\u75db\u6cbb\u7597\u836f\u7269<\/span>\uff0c<\/span>\u63d0\u4f9b\u6bcf\u6708\u4e00\u6b21225\u6beb\u514b\u548c\u6bcf\u5b63\u5ea6\u4e00\u6b21675\u6beb\u514b\u4e24\u79cd\u76ae\u4e0b\u6ce8\u5c04\u65b9\u6848<\/span>16<\/span><\/sup>\u3002\u5728\u76ee\u524d\u5df2\u4e0a\u5e02\u7684CGRP\u5355\u6297\u7c7b\u836f\u7269\u4e2d\uff0c\u827e\u4e45\u7ef4<\/span>\u00ae<\/span><\/sup><\/strong>\u662f\u552f\u4e00\u5177\u6709\u4e0a\u8ff0\u4e24\u79cd\u53ef\u9009\u7ed9\u836f\u65b9\u6848\u7684\u836f\u7269<\/span>3<\/span><\/sup>\u3002\u5b63\u5ea6\u7ed9\u836f\u65b9\u6848\u5927\u5e45\u964d\u4f4e\u6ce8\u5c04\u9891\u6b21\uff0c\u60a3\u8005\u66f4\u5bb9\u6613\u575a\u6301\uff0c\u4ece\u800c\u5728\u6301\u7eed\u7ba1\u7406\u4e2d\u5b9e\u73b0\u53d1\u4f5c\u9891\u7387\u63a7\u5236\u3002\u827e\u4e45\u7ef4<\/span>\u00ae<\/span><\/sup><\/strong>\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u5df2\u83b7\u5f97\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u652f\u6301\u3002\u4e2d\u56fd\u6210\u4eba\u504f\u5934\u75dbIII\u671f\u7814\u7a76\u663e\u793a<\/span>4<\/span><\/sup>\uff0c\u827e\u4e45\u7ef4<\/span>\u00ae<\/span><\/sup><\/strong>\u53ef\u663e\u8457\u51cf\u5c11\u60a3\u8005\u6bcf\u6708\u504f\u5934\u75db\u5929\u6570\uff0c\u5e76\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002<\/span><\/p>\n


<\/p>\n

\u8be5\u4ea7\u54c1\u4e8e2018\u5e74\u9996\u6b21\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u6210\u4eba\u9002\u5e94\u75c7\u6279\u51c6<\/span>3<\/span><\/sup>\uff0c\u5e76\u4e8e2019\u5e74\u7ecf\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u83b7\u6279<\/span>3<\/span><\/sup>\u30022025\u5e74\uff0c\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u9002\u5e94\u75c7\u6269\u5c55\uff0c\u6210\u4e3a\u9996\u4e2a\u7528\u4e8e\u513f\u7ae5\u4e0e\u9752\u5c11\u5e74\u53d1\u4f5c\u6027\u504f\u5934\u75db\u7684CGRP\u9884\u9632\u6027\u6cbb\u7597\u836f\u7269<\/span>3<\/span><\/sup>\u3002<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u5173\u4e8e\u795e\u57fa\u5236\u836f<\/span><\/strong><\/p>\n

\u795e\u57fa\u5236\u836f\uff08NeuroGen Pharma\uff09\u7531\u7a46\u5df4\u8fbe\u62c9\u4e3b\u6743\u57fa\u91d1\u4e0e\u5eb7\u6865\u8d44\u672c\u8054\u5408\u521b\u7acb\uff0c\u4e8e2024\u5e74\u6210\u529f\u6574\u5408\u4f18\u65f6\u6bd4\uff08UCB\uff09\u5728\u534e\u4e94\u5927\u795e\u7ecf\u53ca\u8fc7\u654f\u9886\u57df\u539f\u7814\u8d44\u4ea7\u53ca\u5176\u73e0\u6d77\u751f\u4ea7\u57fa\u5730\u3002<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u4f9d\u6258\u8986\u76d6\u7814\u53d1\u3001\u751f\u4ea7\u53ca\u5546\u4e1a\u5316\u7684\u7aef\u5230\u7aef\u5168\u94fe\u80fd\u529b\uff0c\u516c\u53f8\u805a\u7126\u795e\u7ecf\u53ca\u8fc7\u654f\u9886\u57df\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\uff0c\u5e76\u534f\u540c\u62d3\u5c55\u75bc\u75db\u7ba1\u7406\u9886\u57df\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u6210\u4e3a\u53ef\u6301\u7eed\u589e\u957f\u7684\u751f\u7269\u5236\u836f\u4f01\u4e1a\uff0c\u4ee5\u66f4\u4f18\u8d28\u7684\u8bca\u7597\u65b9\u6848\u548c\u66f4\u53ef\u53ca\u7684\u521b\u65b0\u9009\u62e9\uff0c\u5b88\u62a4\u60a3\u8005\u751f\u547d\u5065\u5eb7\u3002\u4e86\u89e3\u66f4\u591a\uff1a<\/span>www.neurogen.com.cn<\/span><\/span><\/a><\/p>\n


<\/span><\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n

1.\u00a0<\/span>\u56fd\u5bb6\u57fa\u672c\u533b\u7597\u4fdd\u9669\u3001\u5de5\u4f24\u4fdd\u9669\u548c\u751f\u80b2\u4fdd\u9669\u836f\u54c1\u76ee\u5f55\uff082026\u5e74\uff09.<\/span><\/p>\n

2.\u00a0<\/span>Mitsikostas D, et al. Pain Manag. 2025 Nov;15(11):791-800.<\/span><\/p>\n

3.\u00a0<\/span>\u827e\u4e45\u7ef4_\u5728\u534e\u83b7\u6279\uff0c\u7075\u6d3b\u7ed9\u836f\u4e3a\u504f\u5934\u75db\u957f\u671f\u7ba1\u7406\u5e26\u6765\u65b0\u9009\u62e9 https:\/\/mp.weixin.qq.com\/s\/4dmPgbvVKRPhzPhuBQZZ_w<\/span><\/p>\n

4.\u00a0<\/span>Yu S, et al. Cephalalgia, 2026, 46(8): 1\u201313.<\/span><\/p>\n

5.\u00a0<\/span>Silberstein SD, et al. N Engl J Med. 2017 Nov 30;377(22):2113-2122.\u00a0<\/span><\/p>\n

6.\u00a0<\/span>Dodick DW, et al. JAMA. 2018 May 15;319(19):1999-2008.\u00a0<\/span><\/p>\n

7.\u00a0<\/span>Ferrari MD, et al. Lancet. 2019 Sep 21;394(10203):1030-1040.<\/span><\/p>\n

8.\u00a0<\/span>Wang YX, et al. J Headache Pain. 2025 May 6;26(1):104.<\/span><\/p>\n

9.\u00a0<\/span>\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u795e\u7ecf\u5185\u79d1\u533b\u5e08\u5206\u4f1a, \u7b49. \u4e2d\u56fd\u75bc\u75db\u533b\u5b66\u6742\u5fd7, 2022,28(12)881-898.<\/span><\/p>\n

10.\u00a0<\/span>\u4e2d\u534e\u533b\u5b66\u4f1a\u795e\u7ecf\u75c5\u5b66\u5206\u4f1a, \u7b49. \u4e2d\u534e\u795e\u7ecf\u79d1\u6742\u5fd7,2023,56(6):591-613.<\/span><\/p>\n

11.\u00a0<\/span>Charles AC, et al. \u00a0Headache, 2024, 64(4): 333-341.<\/span><\/p>\n

12.\u00a0<\/span>\u4e2d\u534e\u533b\u5b66\u4f1a\u795e\u7ecf\u75c5\u5b66\u5206\u4f1a\u5934\u75db\u534f\u4f5c\u7ec4, \u7b49. \u4e2d\u534e\u795e\u7ecf\u79d1\u6742\u5fd7\uff0c2026, 59 (1): 18\u201333.<\/span><\/p>\n

13.\u00a0<\/span>Efficacy Outcomes From a Phase 3, Randomised, Double<\/span>\u2011<\/span>Blind, Placebo<\/span>\u2011<\/span>Controlled Study of Fremanezumab for the Preventive Treatment of Migraine in Chinese Adults[C]. 20th Migraine Trust International Symposium, London, UK, 2024.<\/span><\/p>\n

14.\u00a0<\/span>\u795e\u57fa\u5236\u836f\u5b98\u7f51\u516c\u544a.<\/span><\/p>\n

15.\u00a0<\/span>2026\u5e7406\u670808\u65e5\u836f\u54c1\u6279\u51c6\u8bc1\u660e\u6587\u4ef6\u9001\u8fbe\u4fe1\u606f.<\/span><\/p>\n

16.\u00a0<\/span>\u592b\u745e\u5948\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\u8bf4\u660e\u4e66. 2026\u5e7406\u670803\u65e5.<\/span><\/p>\n


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